She was born Alice Babette Toklas in San Francisco, California, into a middle-class Jewish family and attended schools in both San Francisco and Seattle. For a short time she also studied music at the University of Washington. She met Gertrude Stein in Paris on September 8, 1907, the day she arrived. Together they hosted a salon that attracted expatriate American writers, such as Ernest Hemingway, Paul Bowles, Thornton Wilder, andSherwood Anderson, and avant-garde painters, including Picasso, Matisse, and Braque.
Toklas published her own literary memoir, a 1954 book that mixed reminiscences and recipes under the title The Alice B. Toklas Cookbook. The most famous recipe therein (actually contributed by her friend Brion Gysin) was called "Haschich Fudge," a mixture of fruit, nuts, spices, and "canibus [sic] sativa," or marijuana. Her name was later lent to the range of cannabisconcoctions called Alice B. Toklas brownies.